For example, they could be used to help quantify the differences between species, calculate the energy consumption in different regions, understand the role of specific types of neurons in different brain regions and the computational properties and capabilities of different brain regions, and map and understand the connectome ( Srinivasan et al., 2015 Weigand et al., 2017). Cell density data could provide constraints when attempting to understand the brain's organization and function. To our knowledge, this is the first attempt to determine the full corpus of knowledge available today on cell densities for all regions of the mouse brain.Įstablishing the numbers of cells in the brain is arguably the first step when developing a complete catalog of cell-types as proposed by the Cell Census Network effort of the BRAIN Initiative ( Bargmann et al., 2014). Here we review what is actually known about total cell density and cell-type specific density in the whole mouse brain and in the different brain regions.
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